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Case 34

Author: Dr. Manon Auger, Dept of Pathology, McGill University, Montreal, Canada

Reviewer: Ritu Nayar, MD., Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

G. Malignant: Squamous cell carcinoma (this is a poorly differentiated squamous cell carcinoma)

A 79 year old man presented with a 2cm nodule in the lingula; no other significant past medical history. 6 static images (Papanicolaou-stained slides) of the direct smear are provided.

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Fig.1. Papanicolaou stain, 400X
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Fig.2. Papanicolaou stain, 400X
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Fig.3. Papanicolaou stain, 400X
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Fig.4. Papanicolaou stain, 600X
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Fig.5. Papanicolaou stain, 600X
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Fig.6. Papanicolaou stain, 600X

Which of the following is the most likely diagnosis?