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Pap Test in an 82-Year-Old Woman with Vaginal Bleeding and an Endocervical Polyp 

Xiangbai Chen, MD¹, Walid E. Khalbuss, MD PhD², Curtis Goldblatt, MD¹, and Liron Pantanowitz, MD²

1. Department of Pathology, Conemaugh Memorial Hospital, Johnstown, PA, USA.
2. Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Fig. 1  Pap test showing many tumor cells dispersed among mature squamous cells (SurePath, Pap stain, original magnification x200).

Fig. 2 Pap test showing tumor cells of varying size with round nuclei and prominent nucleoli (SurePath, Pap stain, original magnification x400).

Fig. 3 Histopathology of the cervical polyp showing sheets of poorly differentiated tumor cells with prominent nucleoli and focal melanin pigment (H&E stain, original magnification x400).

Fig. 4 Strong Melan-A immunoreactivity is shown in melanoma tumor cells surrounding blood vessels (immunohistochemical stain, original magnification x400).

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