Current Concepts and Diagnostic Significance of Molecular Alterations in Salivary Gland Cytopathology
Prof. Dr. med. Niels J. Rupp
Department of Pathology and Molecular Pathology
University Hospital Zurich,
University of Zurich, Zurich, Switzerland
Molecular alterations have significantly advanced the diagnostic precision of salivary gland cytopathology, especially when integrated with systems like the Milan classification. Key genetic changes, such as gene fusions and mutations, help differentiate between benign and malignant lesions and guide targeted therapies for specific tumor subtypes. This webinar provides insights into how these alterations can be used to refine cytological diagnosis in unclear cases.
Date: Thursday, 16. October 2025
Time: 2:00 PM (14:00) European Central Summer Time
After registering, you will receive a confirmation email containing information about joining the meeting and the option to enter the meeting into your digital calendar.
Zoom Link to register: https://us06web.zoom.us/meeting/register/MrtAH8_YR5Sn-oYrJNhjTA
About the Speaker
- Dr. Niels J. Rupp is Senior Attending Physician at the Department of Pathology and Molecular Pathology at the University Hospital Zurich (USZ) and holds an Assistant Professorship for Theragnostic Tumor Pathology at the University of Zurich (UZH), Switzerland.
- His clinical and academic expertise encompasses head & neck pathology, oral & maxillofacial pathology, thyroid pathology, and genitourinary pathology. Prof. Rupp is internationally recognized for his contributions to the molecular cytology of salivary glands.
- He is a co-author of the most recent WHO Classification of Head and Neck Tumours (5th Ed.), as well as the ICCR dataset on carcinomas of the major salivary glands, both of which establish global standards in pathological reporting.
- His research has been instrumental in integrating molecular testing into salivary gland cytology, particularly through next-generation sequencing-based diagnostic panels such as SalvGlandDx, developed by his team. By combining molecular diagnostics with established cytological frameworks such as the Milan classification, his work has significantly advanced diagnostic accuracy in salivary gland lesions.