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IAC Companion Meeting at 2019 USCAP

Sunday, 17. March 2019, 1:30-5:00PM. "When Molecular is Cumbersome... Cytomorphology is There"
Followed by ASC - IAC reception 5:30PM Annapolis 2

2019 header

Link to USCAP website

In our daily practice of histopathology and cytopathology, molecular pathology is often performed most frequently based on the tumor diagnosis, i.e. definitive diagnosis, prognostication and prediction for the therapy. Companion diagnostics generally deal with genomic changes, amplification, mutation, rearrangement, and recently next generation sequencing (NGS).The tissue and cells from the tumors in the various regions are subjected to molecular studies. When we get the molecular results, we usually compare them with morphology. Because of intratumorous heterogeneitiy, correlation between morphological differentiation and the molecular profile is sometimes more complicated. These situations include (1)Thyroid: Mutation of TP53 and BRAFV600E- (morphology) papillary carcinoma with focal anaplastic carcinoma, (2)Salivary gland: Fusion of PLAG1, expression of FHIT and p16INK4a- (morphology) focal carcinoma Ex-pleomorphic adenoma, (3)Neurendocrine tumors(NET): Mutation of TP53 & RB1 and ATRX/ ADXX - (morphology) adenocarcinoma and NET( G3)(MiNEN). On these occasions, we have to look at the cytomorphology in order to understand the molecular changes. In this companion meeting, each speaker on; thyroid (Dr. Syed Ali), lung (Dr. Sinchita Roy), salivary gland (Dr. William Faquin), urine (Dr. Philippe Vielh) and neuroendocrine tumors (NET) (Dr. Robert Y. Osamura) will discuss a case where after the results of the molecular we need to go back to morphology to understand the case. However for a good molecular result we need good material. So, Dr Fernando Schmitt will discuss the preanalytical phase before the cases presentation. The speakers with their broad knowledge on each expertise will clarify how to interpret molecular results with the basis of cytomorphology.

1:30 PM - 1:40 PM, Introduction
Robert Osamura, MD, PhD, FIAC, Nippon Koukan Hospital

1:40 PM - 2:00 PM, Good Molecular Only with Good Material
Fernando Schmitt, MD, PhD, FIAC, IPATIMUP, Medical Faculty of Porto University

2:00 PM - 2:30 PM, When Molecular is Cumbersome... in Thyroid
Syed Ali, MD, FIAC, FRCPath, Johns Hopkins Medical Institutions

2:30 PM - 3:00 PM, When Molecular is Cumbersome... in Lung
Sinchita Roy-Chowdhuri, MD, PhD, The University of Texas MD Anderson Cancer Center

3:00 PM - 3:30 PM, Break

3:30 PM - 4:00 PM, When Molecular is Cumbersome...in Salivary Gland
William Faquin, MD, PhD, Massachusetts General Hospital, Harvard Medical School

4:00 PM - 4:30 PM, When Molecular is Cumbersome...in Neuroendocrine Tumours
Robert Osamura, MD, PhD, FIAC, Nippon Koukan Hospital

4:30 PM - 5:00 PM, When Molecular is Cumbersome... in Urine
Philippe Vielh, MD, PhD, Laboratoire National de Sante

© The International Academy of Cytology